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Download PDF by Mark Ptashne: A Genetic Switch: Phage Lambda Revisited

By Mark Ptashne

ISBN-10: 0879697164

ISBN-13: 9780879697167

The 1st version of Mark Ptashne's 1986 e-book describing the foundations of gene legislation in phage lambda grew to become a vintage in either content material and shape, environment a customary of readability and designated prose that has infrequently been bettered. This version is a reprint of the unique textual content, including a brand new bankruptcy updating the tale to 2004. one of the extraordinary new advancements are contemporary findings on long-range interactions among proteins sure to largely separated websites at the phage genome, and a close description of ways gene activation works.

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Extra info for A Genetic Switch: Phage Lambda Revisited

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10 summarizes the situation. If Cll is highly active the infecting phage lysogenizes; otherwise it grows lytically. Once the decision is made, all other steps of λ growth are determined by one or the other of λ’s developmental programs. 10. The lysis-lysogeny decision. Host proteases regulate the level of activity of CII protein. Although Clll protein is not shown here, the host factors may exert their effects by working on Clll, which protects CII. It is likely that other host proteins regulate translation of the Cll mRNA as well.

As the repressor binds the operator, its arms wrap around and make specific contacts on the backside of the DNA in the major groove. 8 may be an example of a less widely used sequence-reading device. 9 shows Cro’s structure. It includes three α-helices and, in addition, three regions that form so-called λ-sheets. (The λ-sheet is a second common structural motif found in many proteins. 9. Cro. The three flattened arrows represent the segments of a λ-sheet that, in addition to its three α-helices, form Cro’s structure.

To understand how λ repressor uses an α-helix to recognize its operator we must consider the structure of repressor in greater detail than our dumbbell representation in Chapter One. 5, repressor’s amino domain is folded into five successive stretches of αhelix. Alpha-helix 3 lies exposed along the surface of the molecule—this is repressor’s “recognition” helix. In the repressor dimer, the recognition helices—one on each monomer—are separated by the same distance that separates successive segments of the major groove along one face of the DNA.

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A Genetic Switch: Phage Lambda Revisited by Mark Ptashne

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