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Get A Guide to Zona Pellucida Domain Proteins PDF

By Eveline S. Litscher, Paul M. Wassarman

ISBN-10: 0470528117

ISBN-13: 9780470528112

ISBN-10: 1119044723

ISBN-13: 9781119044727

ISBN-10: 1119044766

ISBN-13: 9781119044765

ISBN-10: 1119044995

ISBN-13: 9781119044994

This booklet presents a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details to be had for the zona pellucida area protein kinfolk, which impression pathologies reminiscent of infertility, deafness, and melanoma. moreover it:

  • Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
  • Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
  • Speculates as to the evolution of the ZP area and strength therapeutics for ailments stemming from ZP area mutations
  • Addresses mammalian and non-mammalian systems

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Additional info for A Guide to Zona Pellucida Domain Proteins

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Mol Cell Biol 23, 8982–8991 (2003). 4 Structure of the ZPD As mentioned previously, the ZPD is a bipartite structure consisting of two sub‐ domains, ZP‐N and ZP‐C, linked by a protease‐sensitive region. However, ZP‐N can serve as an independent structural domain since it is present in ZPD proteins Plac1, Oosp1, and papillote in the absence of the ZP‐C sub‐domain. In addition, divergent copies of ZP‐N are found in single or multiple copies in the N‐terminal extensions of ZP1, 2, 4, and ax (Fig. 1).

The ZPD of hamster ZP1 is 82% identical with and 95% similar to the ZPD of mZP1. PLACENTAL MAMMALS 29 1 mawgcfvavl llvatplrlg qhlhskpgle ysydcgvqgm qllviprsnq tirfkvldef 61 gnrfevnncs icyhwvisep hdpavfsady rgchvlqkdg rfhlrvfvqa vlpngyvdta 121 qdvtlicpka dhtvtpdpyl appttpqpft phtfvphtns ghtlagsght lagsghtpll 181 stlypehsfi hstpappspg pgpagptvph pqwgtleple ltkldsvgth ltqeqCqvas 241 ghipCmikss skeaCqqagC CydntrevpC yygntatlqC srsgyftlai sqetalthrv 301 mlnnihlaya psrCpptqkt safvvfhvpl tlCgttiqvv geqliyenql vsnidvqkgp 361 kgsitrdsvf rlhvrCifna sdflpvqasi fspqppapvt qsgplrlelr iakdktfssy 421 yrerdyplar llqepvhvei rllqrtdpgm vlmlhqCwat ptanpfqqpq wpilsdgCpf 481 egdnyrtqmv aldraellfw shyrrftvtt ftlldssags tlrglvyffC sasvCypegs 541 etCstvCdsg marhrrstgh hnstvhaldi vsspgavgfe daaklkpsgs srnsisrpll 601 wvlllllvtt lvlmsl ZP2: The polypeptide of ZP2 consists of 708 aa residues and has a ZPD (aa 363–627; highlighted) with nine Cys residues (aa 364, 395, 416, 457, 537, 607, 612, 622, 626; capitalized and underlined), followed by a CFCS (aa 631–634, RSKR; highlighted and underlined) and a TMD (aa 679–698; highlighted).

Mouse Zp1 encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish. J Biol Chem 270, 27254–27258 (1995). Kinloch RA, Roller RJ, Fimiani CM, Wassarman DA, Wassarman PM. Primary structure of the mouse sperm receptor polypeptide determined by genomic cloning. Proc Natl Acad Sci, USA 85, 6409–6413 (1988). Liang L, Chamow SM, Dean J. Oocyte‐specific expression of mouse Zp2: developmental regulation of the zona pellucida genes. Mol Cell Biol 10, 1507–1515 (1990). Ringuette MJ, Chamberlin ME, Baur AW, Sobieski DA, Dean J.

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A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman


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