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Download e-book for iPad: Adenoviral Vectors for Gene Therapy, Second Edition by David T. Curiel

By David T. Curiel

ISBN-10: 012800276X

ISBN-13: 9780128002766

Adenoviral Vectors for Gene treatment, moment Edition presents designated, accomplished insurance of the gene supply cars which are in line with the adenovirus that's rising as an immense software in gene treatment. those fascinating new healing brokers have nice strength for the remedy of illness, making gene remedy a fast-growing box for learn.

This publication provides subject matters starting from the elemental biology of adenoviruses, throughout the development and purification of adenoviral vectors, state of the art vectorology, and using adenoviral vectors in preclinical animal versions, with ultimate attention of the regulatory concerns surrounding human scientific gene treatment trials. This wide scope of knowledge presents a superior review of the sphere, permitting the reader to achieve a whole knowing of the improvement and use of adenoviral vectors.

  • Provides whole insurance of the fundamental biology of adenoviruses, in addition to their building, propagation, and purification of adenoviral vectors
  • Introduces universal concepts for the advance of adenoviral vectors, in addition to state of the art tools for his or her improvement
  • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
  • Discusses software of adenoviral vectors in animal illness models
  • Considers Federal Drug management laws for human scientific trials

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Additional info for Adenoviral Vectors for Gene Therapy, Second Edition

Example text

Microtubules are polarized filaments composed of α−β tubulin heterodimers. 223 Motor proteins carry cargos across cells along microtubules. 225–228 Adenoviruses exploit the MT motor complex dynein–dynactin to reach the nucleus of epithelial cells. 21,234 HVR1 is susceptible to cleavage by the bacterial protease dispase, and this cleavage abrogated hexon binding to dynein in vitro. 38,173,205 Cues other than low pH are therefore likely to tune the conformation of hexon and promote binding to dynein–dynactin.

Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. J Virol 1998; 72:8806–12. Albinsson B, Kidd AH. Adenovirus type 41 lacks an RGD α(v)-integrin binding motif on the penton base and undergoes delayed uptake in A549 cells. Virus Res 1999;64:125–36. Davison AJ, Telford EA, Watson MS, McBride K, Mautner V. The DNA sequence of adenovirus type 40. J Mol Biol 1993;234:1308–16. Stewart PL, Chiu CY, Huang S, Muir T, Zhao Y, Chait B, et al. Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization.

Virology 2014;450–451:174–81. Schoehn G, El Bakkouri M, Fabry CM, Billet O, Estrozi LF, Le L, et al. Three-dimensional structure of canine adenovirus serotype 2 capsid. J Virol 2008;82:3192–203. Chatterjee PK, Vayda ME, Flint SJ. Interactions among the three adenovirus core proteins. J Virol 1985;55:379–86. Everitt E, Lutter L, Philipson L. Structural proteins of adenoviruses. XII. Location and neighbor relationship among proteins of adenovirion type 2 as revealed by enzymatic iodination, immunoprecipitation and chemical cross-linking.

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Adenoviral Vectors for Gene Therapy, Second Edition by David T. Curiel

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