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Read e-book online Adjuvant Therapies and Markers of Post-Surgical Minimal PDF

By P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)

ISBN-10: 3642813208

ISBN-13: 9783642813207

ISBN-10: 3642813224

ISBN-13: 9783642813221

P. Denoix and G. Mathe nearly 70% of melanoma sufferers relapse after surgical procedure earlier than the fifth 12 months and, normally, for instance in breast carcinoma, they relapse nonetheless later as much as the twentieth 12 months. For a few significant time, the method of melanoma therapy has been constrained to the sophistication of surgery-radiotherapy mixtures that maximally reduced the occurrence of neighborhood and nearby relapses in websites that have been inside of their achieve. this present day, the perform of scientific oncology is unthinkable with no the lively participation of the scientific oncologist. he's the "third guy" of the medical oncology workforce, and he has lately centred cognizance at the indisputable fact that such a lot relapses come up from far away metastases a result of proliferation of cells seeded there after having left the first tumor web site on the time of operation and, therefore, are inaccessible to any shape oflocal and/or neighborhood remedy. in this facts, clinical oncologists have proposed the applying of clinical remedies for disseminated minimum residual affliction (MRD). they've got on hand ability: chemother­ apy and immunotherapy. scientific oncologists mostly should be divided into 3 teams: chemotherapists, immunotherapists, and chemoimmunotherapists. The natural chemotherapists, who had already cured a few malignant neoplasias equivalent to Hodgkin's illness, acute lymphoid leukemia, placental choriocarcinoma, and Wilms' tumor, inspiration they may have the technique of attacking the residual sickness of universal cancers.

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Additional info for Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies

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I I· • •• •• I. • I I I I •• ••••• I •• I • I - I• I • • •• •• • • - •••••••• I. 6000 I I • •• • .... • • Lung cancer I • • •• GOO • Recurrence or metastasis (26 ) .. , • • •• • I' •• • •• ••• •• •• • • • • •••• I l-m) • •• •• • ....... • Undetectable 171 151 Fig. 3. Casein levels in patients with various malignancies FI SRI. FIBRI. 0 FIBRI. E 20 o ~ x ml . ~---:rrr + 10 IT IT O~--------------~----------------J-----------------~ 1 10 100 1000 ng / tube Fig. 4. Displacement curves using K-casein (I + II, II, III + IV), intact fibrinogen, and fragments D and E of fibrinogen 42 J.

In serum, it reaches maximal concentration, about 4 mg/ml in the 12th-14the week offetal age. After birth, its level falls rapidly, within a few weeks, to the adult level of 10-15 ng/ml. In certain pathologic status, abnormal values have been observed. In 1963 ABELEv noted the occurrence of the embryonic aFP in the serum of hepatoma-bearing mice [1]. One year later, Tatarinov reported one case of primary liver carcinoma with a abnormal level of aFP [11]. Since this period, many publications throughout the world have pointed out the diagnostic value of aFP for two types of tumors: primary liver carcinoma and teratocarcinoma with vitelline components [3, 7, 8, 9, 10].

Hendrick et al. I CAS II 10000 2000 500 400 300 200 100 CJ BUFFER ~ UREAGM 20 000 iI'iSIm ng K CAS UREA GM + 1% ME 10000 2000 400 300 200 100 MACROGLOB ZONE y G ZONE ALBUMIN ZONE Fig. 7. K-casein and casein II levels in eluted fractions from chromatographid serum under nondissociating and dissociating conditions References 1. Groves, M. , Gordon, W. : The major component of human casein. A protein phosphorylate at different levels. Arch. Biochem. 140, 47 (1970) 2. Hendrick, J. : Radioimmunoassay of casein in the serum of normal subjects and of patients with various malignancies.

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Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies by P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)


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