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Advances in the Management of Testosterone Deficiency by T. Hugh Jones PDF

By T. Hugh Jones

ISBN-10: 3805586221

ISBN-13: 9783805586221

Testosterone has an enormous effect on significant organ structures and tissues, together with mind, metabolism, cardiovascular in addition to musculoskeletal and immune structures. protecting many scientific parts, this booklet will pay specific consciousness to the analysis and administration of hypogonadism, discussing present instructions, biochemical review, new recommendations in testosterone substitute treatment and long term tracking of taken care of males. moreover the function of testosterone deficiency in getting older, weight problems, muscle functionality and frailty and erectile disorder is covered.Recent proof for the position of testosterone within the pathogenesis of continual illnesses similar to diabetes, heart problems and osteoporosis is stated. New advancements within the capability therapy of those scientific stipulations also are. offered. basically of curiosity to endocrinologists, urologists, andrologists and sexologists, the variety of subject matters lined can be suitable to basic care physicians, gerontologists, diabetologists and cardiologists.

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Additional resources for Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37)

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This report indicates an age-related discrepancy between measured and calculated bioavailable testosterone where the calculated concentration was found to be higher than the measured concentration, probably due to an age-related decrease in adrenal androgens. The ammonium sulphate precipitation technique for measuring bioavailable testosterone, described by Tremblay and Dube [15], is universally recognized as a reliable estimate of the non-SHBG-bound fraction of testosterone. Several reports have testified to this measurement being a satisfactory index of androgen status in men, especially where total testosterone concentrations are borderline hypogonadal [12, 22–24, 26–29].

After a single injection of 50 mg the maximum concentration is reached after approximately 14 h [4]. On the basis of this profile, injection intervals are only 2–3 days with peak and through values above and below the normal range and therefore not suitable for monotherapy of testosterone deficiency. Alternatively, 100 mg weekly may be given. Other testosterone esters are testosterone cypionate and testosterone cyclohexanocarboxylate. The pharmacokinetics of these testosterone esters are very similar to those of TE [4].

0 nmol/l [1] it would appear that a considerably more sensitive assay would be required. There may be scope for applying GC/MS techniques to salivary samples. Although saliva sample collection would be less invasive and more convenient than collecting blood samples, introduction of this medium for routine assessment of gonadal status in men would necessitate all the rigorous procedures of methodology validation including quality control and quality assessment. g. for long-term studies or for more regular assessment of androgen status in men on testosterone replacement therapy.

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Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37) by T. Hugh Jones


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