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Download e-book for kindle: Aging, Sex, and DNA Repair by Carol Bernstein, Harris Bernstein

By Carol Bernstein, Harris Bernstein

ISBN-10: 0120928604

ISBN-13: 9780120928606

ISBN-10: 0323138772

ISBN-13: 9780323138772

Why organisms age and why sexual replica exists are significant unsolved difficulties in biology. This booklet offers an built-in rationalization of getting older and intercourse according to present wisdom of DNA harm and service. Key positive aspects* Discusses the universality of the matter of DNA harm* Describes getting older because of gathered DNA harm* Considers meiosis as an version for DNA fix* Discusses mating in Read more...

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Extra info for Aging, Sex, and DNA Repair

Example text

Repair of thermally induced DNA breakage. Nature 237, 76-79. 2 2 1 1 6 Chapter Three Immediate Consequences of DNA Damage In this c h a p t e r , w e review evidence that the p r e s e n c e of D N A d a m a g e in m a m m a l i a n cells interferes with transcription and replication and c a u s e s cell d e a t h . Cell death a n d / o r progressive impairment of cell function resulting from D N A d a m a g e , we argue in C h a p t e r s 4 - 7 , is the c a u s e of aging in multicellular organisms.

Cox, B. , and Game, J. C. (1974). Repair systems in Saccharomyces. Mutat. Res. 26, 257-264. , Griffiths, T. , and Carpenter, J. G. (1980). Inhibition and recovery of DNA synthesis in UV-irradiated Chinese hamster V-79 cells. Photochem. Photohiol. 32, 157-165. Friedberg, E. C. (1985). " W. H. Freeman and Company, New York. , and Sauerbier, W. (1976). A radiobiological analysis of the transcription units for heterogeneous nuclear RNA in cultured murine cells. Cell 9, 775-783. References ! 35 Hackett, P.

1976). Inhibition and recovery of ribosomal RNA synthesis in ultraviolet irradiated mammalian cells. Biochim. Biophys. Acta 454, 114128. , and Essigman, J. M. (1985). Possible role for thymine glycol in the selective inhibition of DNA synthesis on oxidized DNA templates. Cancer Res. 45,6113-6118. Rupp, W. , and Howard-Flanders, P. (1968). Discontinuities in the 36 I Immediate Consequences of DNA Damage DNA synthesized in an excision-defective strain of Escherichia coli following ultraviolet irradiation.

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Aging, Sex, and DNA Repair by Carol Bernstein, Harris Bernstein

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