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Ola Skold(auth.)'s Antibiotics and Antibiotic Resistance PDF

By Ola Skold(auth.)

ISBN-10: 0470438509

ISBN-13: 9780470438503

ISBN-10: 1118075609

ISBN-13: 9781118075609

This e-book, that is the translated model of a Swedish e-book, combines a normal creation of quite a few antibiotics with a better dialogue of resistance. the point of interest on resistance in studying approximately antibiotics may help destiny scientists realize the matter antibiotics resistance poses for medicinal and drug-related fields, and maybe set off extra study and discoveries to struggle antibiotic resistant lines.

present overviews of the subject are incorporated, in addition to particular discussions at the person mechanisms (betalactams, glycopeptides, aminoglycosides, and so forth) utilized in a number of antibacterial brokers and reasons of ways resistances to these advance. tools for counteracting resistance improvement in micro organism are mentioned as well.

Chapter 1 Antibiotics: the best Triumph of medical drugs (pages 1–19):
Chapter 2 Distribution of Antibiotics (pages 21–28):
Chapter three Sulfonamides and Trimethoprim (pages 29–68):
Chapter four Penicillins and different Betalactams (pages 69–94):
Chapter five Glycopeptides (pages 95–102):
Chapter 6 Aminoglycosides (pages 103–113):
Chapter 7 different Antibiotics Interfering with Bacterial Protein Synthesis (pages 115–131):
Chapter eight Quinolones (pages 133–145):
Chapter nine Antibacterial brokers now not relating to the massive Antibiotic households (pages 147–166):
Chapter 10 Mechanisms for the Horizontal unfold of Antibiotic Resistance between micro organism (pages 167–186):
Chapter eleven tips on how to deal with Antibiotic Resistance (pages 187–202):

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Extra resources for Antibiotics and Antibiotic Resistance

Example text

Specifically, sulfonamides (formula 3-1) were shown to interfere with the bacterial formation of folic acid by its structural similarity to the intermediate p-aminobenzoic acid (3-2). Sulfonamide is generally mentioned in the plural form because dozens of derivatives (modifications at the amino group at the sulfon residue) of Domag’s original sulfanilamide have been synthesized through the years. All of these, however, are identical regarding their antibacterial effect. They have been synthesized only for pharmacokinetic reasons.

Despite the fact that sulfonamides have not long been used for the treatment of streptococcal infections, sulfonamide resistance is common among present isolates of S. pyogenes. This is a further interesting illustration of the nonreversibility of resistance in the absence of the selecting effect of the drug. The drug-resistant phenotypes do not seem to be at any disadvantage in competition with their drug-susceptible relatives. Sulfonamide-resistant strains of S. pyogenes were shown to have very high resistance, some of them with MIC values of 1 mg/mL.

This is an association with representatives from more than 20 different countries. ’’ 28 DISTRIBUTION OF ANTIBIOTICS The total consumption of antibiotics is not alone to blame for the rapid development of resistance. This can be concluded from the resistance situation in developing countries such as Bangladesh, Nigeria, Sri Lanka, and Vietnam, where the consumption of antibiotics per inhabitant is less than a tenth of that in the industrialized world. Still, as described from sporadic reports, the resistance situation is much worse.

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Antibiotics and Antibiotic Resistance by Ola Skold(auth.)

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